Endocrine Abstracts

A 81-year-old woman came to our hospital with complaints of reduction in appetite and weakness of lower limbs. She had developed Cushing’s features. Initial laboratory evaluation revealed severe hypokalemia and hyperglycemia without ketoacidosis, and diabetes mellitus had not been detected previously. A series of hormonal assessment revealed marked ACTH-dependent hypercortisolism. Corticotrophin-releasing hormone stimulation test resulted in normal ACTH response, thus we ...

A 17-year-old male was referred to our hospital with lack of secondary sex characteristics. His voice didn’t break and he lacked of pubes and hircus. His bilateral testicular volume was small and his sense of smell was normal. There was no varicocele or pituitary adenoma. His chromosomal study showed no aberrations. Serum levels of LH, FSH, total testosterone and free testosterone were 1.05 mIU/ml, 1.68 mIU/ml, 0.26 ng/ml and <0.6 pg/ml respectively. A repeated GnRH t...

Introduction: The standard treatment for differentiated thyroid carcinoma (DTC) with distant metastasis comprises complete total thyroidectomy and lymph node dissection, followed by radioactive iodine (RAI) ablation for metastatic lesions. However, between 2014 and 2015, sorafenib and lenvatinib have been approved for treatment of RAI-refractory advanced thyroid cancer in Japan. We retrospectively analyzed how the treatment results have changed after the approval of tyrosine k...